The use of mesenchymal stem cell therapy in the regeneration and repair of damaged cartilage in osteoarthritis
Keywords:
Osteoarthritis, aging, mesenchymal cells, pluripotency, regenerationAbstract
Osteoarthritis (OA) is a highly prevalent, multifactorial pathology that mainly affects older adults. It is projected that by 2050 there will be 1.6 billion people in this age group, which makes the development of a useful therapy for OA essential in its development. OA mainly affects cartilage, damaging and weakening it, causing chronic pain, inflammation and a loss of quality of life for the patient who suffers from it. This study aims to demonstrate the benefits of new therapies focused on cartilage regeneration, such as regenerative therapy with mesenchymal cells (MSC) with the aim of being considered as an option in our country to treat these patients. This is a systematic review of the bibliography, of a qualitative nature, of books and scientific publications that have been published during the last 5 years in English and Spanish on therapy with mesenchymal cells to regenerate and repair damaged cartilage in osteoarthritis. databases such as PubMed, Scopus, Web of Science and ScieLO. MSCs are an innovative therapeutic that still require more studies in order to provide the greatest therapeutic benefit in OA. The most effective MSCs are autologous ones since they have lower rejection rates and greater regenerative benefit. The best route of administration is localized as it specifically promotes cellular benefits in the affected tissue.
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