Management of neuropsychiatric symptoms in patients with dementia in palliative care

Authors

Keywords:

Neuropsychiatric symptoms, psychomotor agitation, palliative care, delirium, neurocognitive disorders

Abstract

The treatment of neuropsychiatric symptoms in palliative care directly influences the patient's quality of life. The aim of the study is to describe the current recommendations for the management of neuropsychiatric symptoms in palliative care. Clinical guidelines from the last 10 years were taken from databases such as Pubmed, TripDatabase and Google Scholar. With a strategy based on Mesh/DecS terms and Boolean operators. The PRISMA methodology was followed. 16 clinical practice guidelines on the management of neuropsychiatric symptoms were analyzed, in which it was observed that there are two treatment approaches: non-pharmacological and pharmacological. The first includes control of factors such as dehydration, pain, hyponatremia or hypoglycemia, in addition to environmental control, exposure to sunlight, and various strategies to achieve relaxation. The pharmacological approach involves using psychotropic drugs such as haloperidol, along with benzodiazepines, if there is no adequate response with non-pharmacological management. It was shown that adequate management of neuropsychiatric symptoms in palliative care is based on multidimensional care that not only focuses on reducing physical symptoms, but also considers the emotional and social well-being of the patient and his or her family.

Downloads

Download data is not yet available.

Author Biography

Diego Raúl Bonifaz-Díaz, Universidad Iberoamericana. Ecuador.

 

 

References

Anneser, J., Arenz, V., & Borasio, G. D. (2018). Neurological Symptoms in Palliative Care Patients. Frontiers in Neurology, 9(2), 145–159. https://doi.org/10.3389/fneur.2018.00275

Britt, K. C., Richards, K. C., Kesler, S., Acton, G., Hamilton, J., & Radhakrishnan, K. (2023). The Association of Private Prayer with Neuropsychiatric Symptoms, Cognition, and Sleep Disturbances in Persons with Dementia (Sci255). Journal of Pain and Symptom Management, 65(5), 670–681. https://doi.org/10.1016/j.jpainsymman.2023.02.305

Canadian Coalition for Seniors’ Mental Health. (2024). Canadian Clinical Practice Guidelines for Assessing and Managing Behavioural and Psychological Symptoms of Dementia (BPSD). https://ccsmh.ca/wp-content/uploads/2024/03/CCSMH-BPSD-Clinical-Guidelines_FINAL_March-2024.pdf

Chan, L., & Corso, G. (2024). Pharmacological and non-pharmacological prevention and management of delirium in critically ill and palliative patients in the inpatient setting: a review. Frontiers in Medicine, 11(17), 11–19. https://doi.org/10.3389/fmed.2024.1403842

Cummings, J., Lanctot, K., Grossberg, G., & Ballard, C. (2024). Progress in Pharmacologic Management of Neuropsychiatric Syndromes in Neurodegenerative Disorders. JAMA Neurology, 81(6), 645–652. https://doi.org/10.1001/jamaneurol.2024.0586

Ecuador. Ministerio de Salud Pública. (2014). Cuidados paliativos. Guía de Práctica Clínica. http://hgona.gob.ec/index.php/gpc-cuidados-paliativos-completa/

García, V., De Hoyos, M., Ariza, G., Delgado, R., García, P., Hernández, E., De Haro-de Torres, J., & Del Cura-González, I. (2022). Neuropsychiatric symptoms and subsyndromes in patients with different stages of dementia in primary care follow-up (NeDEM project): a cross-sectional study. BMC Geriatrics, 22(1), 71–83. https://doi.org/10.1186/s12877-022-02762-9

Grassi, L., Caruso, R., Riba, M. B., Lloyd-Williams, M., Kissane, D., Rodin, G., McFarland, D., Campos-Ródenas, R., Zachariae, R., Santini, D., & Ripamonti, C. I. (2023). Anxiety and depression in adult cancer patients: ESMO Clinical Practice Guideline. ESMO Open, 8(2). https://doi.org/10.1016/j.esmoop.2023.101155

Greater Manchester Medicines Management, & Group. (2022). Palliative care pain & symptom control guidelines for adults for staff providing generalist palliative care. https://www.england.nhs.uk/north-west/wp-content/uploads/sites/48/2020/01/Palliative-Care-Pain-and-Symptom-Control-Guidelines.pdf

Johanna Briggs Institute. (2020). Critical Appraisal Tool. https://jbi.global/critical-appraisal-tools

Kawashima, N., Yokomichi, N., Morita, T., Yabuki, R., Hisanaga, T., Imai, K., Hirose, Y., Shimokawa, M., Miwa, S., Yamauchi, T., Okamoto, S., & Satomi, E. (2024). Comparison of Pharmacological Treatments for Agitated Delirium in the Last Days of Life. Journal of Pain and Symptom Management, 67(5), 441–452. https://doi.org/10.1016/j.jpainsymman.2024.02.008

Lorusso, L. N., & Bosch, S. J. (2018). Impact of Multisensory Environments on Behavior for People With Dementia: A Systematic Literature Review. The Gerontologist, 58(3), 168–179. https://doi.org/10.1093/GERONT/GNW168

Maters, J., van der Steen, J. T., de Vugt, M. E., Bakker, C., & Koopmans, R. T. C. M. (2024). Palliative Care in Nursing Home Residents with Young-Onset Dementia: Professional and Family Caregiver Perspectives. Journal of Alzheimer’s Disease, 97(2), 573–586. https://doi.org/10.3233/JAD-230486

National Cancer Grid. (2021). NCG Palliative Care Guidelines – End of Life Care. https://www.ncgindia.org/assets/palliative-care-guidelines/approach-to-managing-end-of-life-care.pdf

National Coalition for Hospice and Palliative Care. (2018). Clinical Practice Guidelines for Quality Palliative Care, 4th edition. National Coalition for Hospice and Palliative Care.

National Institute for Health and Excellence. (2015). Care of dying adults in the last days of life. https://www.ncbi.nlm.nih.gov/books/NBK338140/

North East and North Cumbria. (2021). Palliative and End of Life Care Symptom Control Guidelines for cancer and non-cancer patients. https://northerncanceralliance.nhs.uk/wp-content/uploads/2022/06/20220615-Palliative-and-End-of-Life-Care-Guidelines-2021-DOWNLOAD.pdf

North West Coast Clinical Network. (2024). Palliative Care Guidelines in Dementia 3rd Edition. https://www.england.nhs.uk/north-west/wp-content/uploads/sites/48/2024/11/Palliative-Care-Guidelines-in-Dementia-3rd-ed-Nov-2024-PDF-VERSION-1.pdf

Northern England Clinical Networks. (2016). Palliative and End of Life Care Guidelines Symptom control for cancer and non-cancer patients. https://www.northerncanceralliance.nhs.uk/wp-content/uploads/2018/11/NECNXPALLIATIVEXCAREX2016-1.pdf

Page, M., McKenzie, J., Bossuyt, P., Boutron, I., Hoffmann, T., Mulrow, C. D., Shamseer, L., Tetzlaff, J., Akl, E., Brennan, S., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., & Moher, D. (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ, 2(4), 71–75. https://doi.org/10.1136/bmj.n71

Parker, D., Lewis, J., & Gourlay, K. (2016). Palliative Care and dementia. https://www.dementia.org.au/sites/default/files/2024-02/DA-Numbered-Publication-43-Palliative-care-and-dementia.pdf

Pless, A., Ware, D., Saggu, S., Rehman, H., Morgan, J., & Wang, Q. (2023). Understanding neuropsychiatric symptoms in Alzheimer’s disease: challenges and advances in diagnosis and treatment. Frontiers in Neuroscience, 17, 1263771. https://doi.org/10.3389/FNINS.2023.1263771/BIBTEX

Radbruch, L., De Lima, L., Knaul, F., Wenk, R., Ali, Z., Bhatnaghar, S., Blanchard, C., Bruera, E., Buitrago, R., Burla, C., Callaway, M., Munyoro, E. C., Centeno, C., Cleary, J., Connor, S., Davaasuren, O., Downing, J., Foley, K., Goh, C., & Pastrana, T. (2020). Redefining Palliative Care—A New Consensus-Based Definition. Journal of Pain and Symptom Management, 60(4), 754–764. https://doi.org/10.1016/j.jpainsymman.2020.04.027

Rezaei, F., Reamazannezhad, N., Douki, M., Shayadeh, F., Nejati, E., & Ahmadian, Z. (2020). Nursing care (palliative medicine) in patients with neuropsychiatric disorders. Journal of Family Medicine and Primary Care, 9(1), 25–30. https://doi.org/10.4103/jfmpc.jfmpc_701_19

Sano, M., Cummings, J., Auer, S., Bergh, S., Fischer, C. E., Gerritsen, D., Grossberg, G., Ismail, Z., Lanctôt, K., Lapid, M. I., Mintzer, J., Palm, R., Rosenberg, P. B., Splaine, M., Zhong, K., & Zhu, C. W. (2024). Agitation in cognitive disorders: Progress in the International Psychogeriatric Association consensus clinical and research definition. International Psychogeriatrics, 36(4), 238–250. https://doi.org/10.1017/S1041610222001041

Scottish Intercollegiate Guidelines Network. (2023). Assessment, diagnosis, care and support for people with dementia and their careers 2023. https://www.sign.ac.uk/our-guidelines/assessment-diagnosis-care-and-support-for-people-with-dementia-and-their-carers/

Shin, J., Chang, Y. J., Park, S.-J., Choi, J. Y., Kim, S.-H., Choi, Y. S., Kim, N. H., Yum, H.-K., Nam, E. M., Park, M. H., Moon, N., Moon, J. Y., Kang, H.-T., Kang, J. H., Park, J.-M., Lee, C.-W., Kim, S.-Y., Lee, E. J., Koh, S.-J., & Shim, J. Y. (2020). Clinical Practice Guideline for Care in the Last Days of Life. The Korean Journal of Hospice and Palliative Care, 23(3), 103–113. https://doi.org/10.14475/kjhpc.2020.23.3.103

Walsh, S. C., Murphy, E., Devane, D., Sampson, E. L., Connolly, S., Carney, P., & O’Shea, E. (2021). Palliative care interventions in advanced dementia. Cochrane Database of Systematic Reviews, (9), 2–17. https://doi.org/10.1002/14651858.CD011513.pub3

Wendrich-van Dael, A., Bunn, F., Lynch, J., Pivodic, L., Van den Block, L., & Goodman, C. (2020). Advance care planning for people living with dementia: An umbrella review of effectiveness and experiences. International Journal of Nursing Studies, 107(2), 103–115. https://doi.org/10.1016/j.ijnurstu.2020.103576

Wessex Palliative Physicians. (2019). The Palliative Care Handbook. https://www.ruh.nhs.uk/for_clinicians/departments_ruh/palliative_care/documents/palliative_care_handbook.pdf

World Health Organzation. (2020). Palliative care. https://www.who.int/news-room/fact-sheets/detail/palliative-care

Yorkshire and the Humber Health and Care Partnership. (2024). A Guide to Symptom Management in Palliative Care. https://humberandnorthyorkshire.org.uk/wp-content/uploads/2024/05/A-Guide-to-Symptom-Management-in-Palliative-Care-v8-Approved-by-HNY-IPMOC-February-2024.pdf

Published

2025-01-01

How to Cite

Escobar-Morillo, A. L., & Bonifaz-Díaz, D. R. (2025). Management of neuropsychiatric symptoms in patients with dementia in palliative care. Revista UGC, 3(1), 191–201. Retrieved from https://universidadugc.edu.mx/ojs/index.php/rugc/article/view/87