Metabolic biochemical parameters in obese diabetics undergoing bariatric surgery. A systematic review

Authors

Keywords:

Metabolic biomarkers, type 2 diabetes mellitus, obesity, bariatric surgery

Abstract

The worst metabolic consequence of obesity is type 2 diabetes mellitus (DM2), which substantially increases morbidity and mortality, leading to diabesity. Bariatric surgery has proven to be an effective method to achieve DM2 remission in people with obesity, providing long-lasting metabolic control and decreasing drug dependence. The aim of the study was to analyze metabolic biochemical parameters in patients with obesity before and after bariatric surgery. A systematic review was conducted, taking as sources of information scientific articles published in specialized databases such as Pubmed, Cochrane library, Scielo, and Google scholar. A search strategy based on Mesh/DeCS terms and Boolean operators was followed. Articles from 2019-2024 were included, with adult patients with type 2 diabetes mellitus and obesity (BMI ≥ 30 kg/m²), undergoing bariatric surgery, where the effects of surgery on metabolic parameters such as glucose, insulin, Homa-IR index, glycated hemoglobin (HbA1c) and C-peptide before and after bariatric surgery are investigated. The PRISMA methodology was followed. 2014 articles were identified, of which 12 were selected. In all the articles analyzed, a significant reduction in the values ​​of glucose, insulin, HbA1c, HOMA-IR index and C-peptide after surgery is reported; In addition, complete diabetes remission was reported to be more likely among those who received gastric bypass. Evidence is provided of the effect of bariatric surgery on metabolic biomarkers of DM2, which positions it as an effective and safe option for patients with diabetes.

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References

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Published

2025-01-01

How to Cite

Veintimilla-Verdezoto, V. F., & Bonifaz-Díaz, D. R. (2025). Metabolic biochemical parameters in obese diabetics undergoing bariatric surgery. A systematic review. Revista UGC, 3(1), 202–211. Retrieved from https://universidadugc.edu.mx/ojs/index.php/rugc/article/view/88

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Vol. 3 No. 1 (2025): Enfoque multidisciplinario en las ciencias (Enero-abril)

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Copyright (c) 2025 Verónica Fernanda Veintimilla-Verdezoto, Diego Raúl Bonifaz-Díaz

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